This network of laboratories provides state-of-the-art services for analyzing biological samples and understanding biological responses associated with environmental exposures.
The Laboratory Network:
- Targeted Analysis
Hypothesis-driven analyses of specific contaminants, markers of exposure, and other substances known or suspected to affect health outcomes. Examples include specific pesticides in biological fluids and biomarkers of tobacco smoke exposure. Targeted analyses are typically performed for panels of chemically related compounds.
- Untargeted Analysis
Hypothesis-free exploratory analyses using advanced technologies to discover new associations between chemicals or metabolites and health. Both endogenous metabolites and exogenous xenobiotics can be identified and measured. Techniques may include nuclear magnetic resonance (NMR) and mass spectrometry (MS) metabolomics.
- Biological Response
Measurements of individual response to environmental stressors using established markers. Examples include measures of immune activation or inflammation and measures of response to psychosocial stress. CHEAR will provide analyses of biological response indicators only as secondary analyses in connection with targeted or untargeted exposure assessments.
The network comprises principal investigators and laboratory core directors with expertise in exposure science, environmental epidemiology, and child development at six Lab Hubs:
- The National Exposure Assessment Laboratory at Emory
- M-CHEAR: Michigan Children's Health Exposure Analysis Resource Laboratory Hub
- Minnesota CHEAR Exposure Assessment Hub
- Mount Sinai CHEAR Network Laboratory Hub
- RTI CHEAR Exposure Assessment Hub
- Wadsworth Center's Children's Health Exposure Assessment Resource (WCCHEAR)
Other CHEAR Components: